O-乙基-N-烷基-N′-乙氧羰基甲基-N′-苯磺酰基磷酰二胺酯类化合物的研究

Studies on N-Alkyl-N' -Phenylsulfonyl-N' -Ethoxycarbonylmethyl-O-Ethylphosphorodiamidoates

本文报告了10种新的O-乙基-N-烷基-N′-乙氧羰基甲基-N′-苯磺酰基磷酰二胺酯类化合物EtO(R_1R_2N)P(O)N(CH_2CO_2Et)SO_2(Ⅰ)的制各方法,经~1H NMR己及元素分析证明了(Ⅰ)的结构;对合成中的“一锅法”反应进行了探讨;初步生物测试表明其中有些化合物对小麦锈病有显著的抑制作用。

The method for the synthesis of ten new phosphorodiamidoates with a general formula: EtO(R,R2N)P(O)N(CH2CO2Et)SO2C6H4X ( I ), (where R,,R2 = H and lower alkyl groups, X = Me, halogen and nitro groups) is described. The structures of ( I ) were confirmed by 'H NMR and elemental analysis, A one-pot reaction was investigated; the preliminary bioassay shows.that some of these new compounds have a remarkable inhibitory effect on leaf-rust of wheat.