幽门螺杆菌感染与胃肠外疾病的关系

Helicobacter pylori Infection and Extragastic Diseases

流行病学研究显示幽门螺杆菌可能与某些胃肠外疾病发生有关,根除治疗可能缓解缺铁性贫血、ITP、酒糟鼻等疾病的临床症状和实验室异常。从粥样硬化相关心血管疾病、血液系统疾病、皮肤病的研究结果看,尽管有证据显示该类疾病患者幽门螺杆菌感染率高于普通人群,但二者是因果还是伴随现象仍不得而知,同时尚无根除治疗远期效果的报道。对相关胃肠外疾病是否需要进行幽门螺杆菌检测和治疗尚无定论。鉴于流行病学研究的局限性和发病机制的不确定性,对二者关系应持慎重态度,避免对幽门螺杆菌检测和根除治疗的过度滥用。二者关系的阐明有待机制研究的进展。

Epidemidogical data have shown that there are maybe somne connection between Helicobacter pylori infection and some extragastric diseases, and the eradication therapy might release the symptoms and lab abnormalities of some diseases such as iron deficiency anemia, ITP and brandy nose. It was reported that the prevalence of Helicobacter pylori infection in patients with atherosclerosis, hematological and dermatologic diseases was significantly higher than that in population. But we didn＇t know it is cause-effect or just synchronization. And there were no study on the long- term follow- up of the effect of eradication therapy. We should avoid the abuse of Helicobacter pylori detection and eradication indications. The study on the mechanism may be helpful.