复合还原剂硼氢化钠/铁盐对腈的还原

Reduction of Nitriles with Combined Reducing Agent——Sodium Borohydride/Iron Salts

硼氢化钠是一种温和的选择性还原剂,在一般条件下只能还原醛、酮和酰卤,对其它化合物,如亚砜、腈等则不起作用,因而限制了其应用范围。据文献据道,某些金属盐能有效地提高硼氢化钠的还原能力,最近我们报道了硼氢化钠和六水合三氯化铁在还原亚砜为硫醚的反应中,此复合还原剂比其它试剂具有明显的优点,本工作继续研究了硼氢化钠/铁盐还原腈类化合物为相应的伯胺的反应。

Under mild conditions both aromatic and aliphatic nitriles were reduced to corresponding primary amines by combined reducing agent----------sodium borohydride/ferric chloride in moderate yields. The effect of various solvents and metal salts on the reduction were studied. The reaction mechanism was also discussed.