甲状腺机能亢进症患者血清微量元素谱的计算机模式识别研究

Study on serum trace elements score of hyperthyroidism by computer pattern recognition

目的探讨甲亢患者血清微量元素谱的变化及其与甲状腺功能状态的关系。方法对照组60例,甲亢组67例,测定血清微量元素(Mg、Ca、Cr、Mn、Fe、Cu、Zn、Sr、Mo和Ba)以及甲状腺激素(FT3、FT4)水平,比较两组间各微量元素的差异;并将甲亢患者各微量元素与FT3、FT4分别作相关分析;采用计算机模式识别技术中的马氏距离判别法,作多因素分类判别,筛选特征参量。结果甲亢组血清Zn、Mg和Cr水平降低,Cu、Fe、Ca和Mn水平升高,与对照组比,差异有显著性(P<0.01,P<0.05),Sr、Mo和Ba水平无显著变化;且血清Zn、Mg与FT3、FT4水平呈负相关,血清Cu与FT3、FT4水平呈正相关;甲亢患者微量元素谱的特征参量为:Zn、Fe、Cu、Ca和Mn。结论甲亢患者存在血清微量元素谱的变化,微量元素与甲状腺功能状态相互关联,微量元素在甲亢的病理生理机制中可能起着重要作用。

[Objective] To investigate the changes of serum trace dements score of patients with hyperthyroidism and its relationship with thyroid function. [Methods] The serum trace elements （Mg, Ca, Cr, Mn, Fe, Cu, Zn, Sr, Mo, Ba） and thyroid hormones （FT3, FT4） were measured in control group （n =60） and hyperthyroidism group （n =67）. The difference of serum trace elements was compared in two groups. The relationship of serum trace elements with thyroid hormones was analyzed in hyperthyroidism group. The character parameter was selected by Mahalanobis distance decision method （Computer pattern recognition technique）. [ Results ] The levels of serum trace elements Zn, Mg, Cr significandy reduced （P 〈0.01, P〈0.05）, Cu, Fe, Ca, Mn significandy increased （P〈0.01, P 〈0.05）, and Sr, Mo, Ba not significantly changed in the hyperthyroidism group than those in control group; Zn, Mg were related negatively to FT3, FT4 and Cu was positively related to FT3, FT4; Zn, Fe, Cu, Ca and Mn were selected as the character parameter in hyperthyroidism. [Conclusion] The serum trace elements score was changed in patients with hyperthyroidism. The trace elements may influence the thyroid function each other, and play an important role in the pathophysiology of the hyperthyroidism.