摘要
目的探讨乌贼墨对实验性高脂血症大鼠血脂代谢和抗氧化能力的影响。方法饲喂高脂饲料建立高脂血症大鼠模型,同时灌胃乌贼墨,剂量分别为50和200 mg.kg-1,连续30d。分别测定大鼠血清总胆固醇(TC),甘油三酯(TG),低密度脂蛋白胆固醇(LDL-c),高密度脂蛋白胆固醇(HDL-c)和一氧化氮(NO)含量,以及大鼠血清和肝脏丙二醛(MDA)含量,超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)活性。结果乌贼墨能显著性降低模型大鼠血清中的TC,TG和LDL-c含量,升高HDL-c,降低动脉粥样硬化指数(LDL-c/HDL-c);显著提高高脂血症大鼠血清中NO含量;显著降低血清及肝组织中MDA含量,提高SOD和GSH-Px活性。结论乌贼墨可通过调节机体血脂代谢、提高机体内源性抗氧化酶活性,降低机体的过氧化水平,有效预防高脂血症的形成。
Objective To investigate the effects of sepia on blood lipid and peroxidation in hyperlipidemia rats. Methods The hyperlipemia model rats were established by feeding with high fat diet; meanwhile, the rats were ig sepia at dose of 50 and 200mg· kg^1, respectively. The contents of total cholesterol （TC）, triglyceride （TG）, low density lipoprotein-cholesterol（LDL-c）, high density lipoprotein- cholesterol（HDL-c） and NO in serum, the contents of malondialdehyde （MDA）, the activities of superoxide dismutase （SOD） and glutathione peroxidase（GSH-Px） in serum and liver were examined on the 30th day. Results The sepia could decrease the contents in serum TC, TG, I.DL-c and increase serum HDL-c significantly, remarkably decreased the contents in serum and liver MDA, enhance the activities of serum and liver SOD , GSH-Px markedly. Conclusion The sepia can modulate the level in blood lipid and improve the antioxidation ability in hyperlipidemia rats.
出处
《中国海洋药物》
CAS
CSCD
2007年第3期30-33,共4页
Chinese Journal of Marine Drugs
基金
新世纪优秀人才支持计划项目(NCET-04-0642)
国家自然科学基金项目(No.30471319)
国家"863"高技术研究与发展项目(2005AA625010)
关键词
乌贼墨
血脂代谢
抗氧化
sepia
metabolization of blood lipid
antioxidation ability
