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GLP-1抗糖尿病作用研究进展 被引量:8

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作者 傅勇 李蓬秋
出处 《实用糖尿病杂志》 2007年第3期53-55,共3页 Journal of Practical Diabetology
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  • 1Kieffer,T.J.,McIntosh,C.H.S,Pederson R.A.Degradation of glucose-dependent Insulinotropic poly peptide and truncated glucagon-like peptide 1 in vitro and in vitro by dipeptidylpeptidase IV.Endocrinology 1995;136:3585-3596.
  • 2Hoist JJ,Orskov C,Nieleen OV,et al.Truncated ghcagonslike peptide I,an insulin-releasing hormone from the distal gut.FEBS Lett,1987 Jan 26;211(2):169-174.
  • 3Nauck MA,Heimesaat MM.Behle K.et al.Efleets of glucagon-like peptide 1 on counterregulatory hormone responses.cognitive functions,and insulin secretion during hyperinsulinemic,stepped hypoglyeemic clamp experiments in healthy volunteers.J Clin Endocrinol Metab 2002;87:1239-1246.
  • 4Widmann C,Dolci W.Thorens B.Internalization and homologous desensitization of the GLP-1 Receptor depend on phosphorylation of the receptor carboxyl tail at the same three Sites[J].diabetes 2001:50:2237-2243.
  • 5Farilla L.Bulotta A,Hisrshberg B,et al.Glucagon like peptide -1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets[J].Endocrinology 2003;144(12):5149-5158.
  • 6Hui H,NourparvarA,Zheo X,et al.GIucagon-like pepfide-1 inhibits cell apoptosis of insulin-secreting cells via a cyclic 5'-adenosine monophosphate-dependent protein kinase A-and a phosphatidylinositol 3-kinase-dependent pathway.Endocrinology 2003;144:1444-1445.
  • 7Susini,S,Roche,E,Prentki.M,Schegel,w.Glucose and glucoincretin peptides synergize To induce c-fos,cjun.junB,zif-268,and nur-77 gene expression in pancreatic b(1NS-1)cells.FASEB J 12;1173-1182(1998).
  • 8Zhou J,Wang X,Pineyro MA et al.GIucagon-like pepfide 1 and exendin一4 convertpancreatic AR42J cells into glucagous and insulin-producing cells.Diabetes 1999;48:2358-2366.
  • 9Abraham EJ,Leech CA,Lin JC,et al.Insulinotropic hormone glucagous-like peptide-1 defferentition of human pancreatic isletderived progenitor ceils intoinsulin-producing cells.endocrinology 2002;143:3152-3161.
  • 10Freyse EJ,Becher T,E1 Hag O,et al.Blood glucose lowering and glucagonostatic effect of glucagon-like peptide l in insulin-deprived diabetic dogs.Diabetes 1997;46:824-828.

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