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脂联素与冠心病关系的研究进展 被引量：2

Relationship between adiponectin and coronary heart disease
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摘要 脂联素(APN)是脂肪组织分泌的一种细胞因子。具有增强胰岛素敏感性、调节糖脂代谢、抗动脉粥样硬化、抗炎症等诸多作用,与冠心病的发生发展密切相关。 Adiponectin is a cell factor which is mainly secreted by adipose tissue, has a role in increasing insulin sensitivity, glucolipid metabolism regulation, anti-arteriosclerosis and anti-inflammation. It is closely related to coronary heart disease.
作者 李敬伟 党群
机构地区 天津市第一中心医院
出处 《中国心血管杂志》 2007年第3期224-226,共3页 Chinese Journal of Cardiovascular Medicine
关键词 脂联素 冠心病 动脉粥样硬化 Adiponectin Coronary heart disease Arteriosclerosis
分类号 R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献21

  • 1Pajvani UB,Du X,Combs TIP,et al.Structure-function studies of the adipocyte-aecreted hormone Acrp30/adiponectin:implications for metabolic regulation and bioactivity[J].J Biol Chem,2003,278:9073-9085.
  • 2Pajvani UB,Hawkins M,Combs TP,et al.Complex distribution,not absolute amount of adiponectin,correlates with thiazolidinedione-mediated improvement in insulin sensitivity[J].J Biol Chem,2004,279:12152-12162.
  • 3Kobayashi H,Ouchi N,Kihara S,et al.Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin[J].Circ Res,2004,94:e27-31.
  • 4Vasseur F,Helbecque N,Dina C,et al.Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gone modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians[J].Human Molecular Genetics,2002,11:2607-2614.
  • 5Weyer C,Funahashi T,Tanaka S,et al.Hypoadiponectinemia in obesity and 2 diabetes:close association with insulin resistance and hyperinsulinemia[J].J Clin Endocrinol Metab,2001,86:1930-1935.
  • 6Hotta K,Funahashi T,Bodkin N L,et al.Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys[J].Diabetes,2001,50:1126-1133.
  • 7Pischon T,Girman CJ,Hotamisligil GS,et al.Plasms adiponectin levels and risk of myocardial infarction in men[J].JAMA,2004,291:1730-1737.
  • 8Matsuda M,Shimomura I,Sata M,et al.Role of adiponectin inpreventing vascular stenosis,The missing link of adipovascular axis[J].J Biol Chem,2002,277:37487-37491.
  • 9Yoshihisa O,Shinji K,Noriyuki O,et al.Adiponectin reduces atherosclerosisin apolipoprotein E-deficient mice[J].Circulation,2002,106:2767-2770.
  • 10Yamauchi T,Kamon J,Waki H,et al.Globular adiponectin protected ob/ob mice from diabetes and ApoE deficient mice from atherosclerosis[J].J Bio1 Chem,2003,278:2461-2468.

二级参考文献23

  • 1刘军,陈影,刘芳,姚庆姑,许火根,澎名淑,郭瑜琳,陈钦达.2型糖尿病家系非糖尿病一级亲属脂联素水平与胰岛素抵抗和动脉粥样硬化相关性研究[J].中华内分泌代谢杂志,2004,20(3):215-216. 被引量：30
  • 2Okamoto Y, Arita Y, Nishida M, et al. An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls. Horm Metab Res, 2000,32:47-50.
  • 3Ouchi N, Kihara S, Arita Y, et al. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-κB signaling through a cAMP-dependent pathway. Circulation, 2000,102:1296-1301.
  • 4Yokota T, Oritani K, Takahashi I, et al. Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood, 2000,96:1723-1732.
  • 5Matsuda M, Shimomura I, Sata M, et al. Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis. J Biol Chem, 2002,277:37487-37491.
  • 6Kubota N, Terauchi Y, Yamauchi T, et al. Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem, 2002,277:25863-25866.
  • 7Arita Y, Kihara S, Ouchi N, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.Biochem Biophys Res Commun, 1999,257:79-83.
  • 8Hotta K, Funahashi T, Arita Y, et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol, 2000,20:1595-1599.
  • 9Kumada M, Kihara S, Sumitsuji S, et al. Association of hypoadi-ponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol, 2003,23:85-89.
  • 10Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol, 1983,51:606.

共引文献110

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二级引证文献11

中国心血管杂志
2007年 第3期

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