期刊文献+

促红细胞生成素与心肌缺血再灌注损伤 被引量:2

Erythropoietin and myocardial ischemia/reperfusion injury
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摘要 近年来促红细胞生成素(erythropoietin,EPO)的非造血生物作用逐渐引起关注。研究表明,EPO 可以减轻缺血缺氧时心肌细胞的损伤,减少心肌细胞的调亡,从而使其可能成为预防和治疗心肌缺血再灌注损伤的一条途径。 In recent years, the non-hematopoietic biological effects of erythropoietin (EPO) have drawn more attention. Some studies have demonstrated that EPO can mitigate cell damage and reduce myocardial tissue apoptosis under hypoxia/ischemia stress. EPO treatment can be a new pathway to protect the myocardial tissue from ischemia/reperfusion injury.
出处 《中国心血管杂志》 2007年第3期227-228,共2页 Chinese Journal of Cardiovascular Medicine
关键词 缺血再灌注损伤 促红细胞生成素 Ischemia/reperfusion injury Erythropoietin
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参考文献14

  • 1Maiese K,LI F,Chong ZZ.New avenues of exploration for erythropoietin[J].JAMA,2005,293:90-95.
  • 2Savino R,Ciliberto G.A paradigm shift for erythropoietin:no longer a specialized growth factor.but rather an all-purpose tissue-protective agent[J].Cell Death Difer,2004,11(Suppl 1):S2-S4.
  • 3Parsa CJ,Matsumoto A,Kim J,et al.A novel protective effect of erythropoietin in the infarcted heart[J].J Clin Invest,2003,112:999-1007.
  • 4Calvillo L,Latini R,Kajstura J,et al.Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling[J].Proc Natl Acad Sci USA,2003,100:4802-4806.
  • 5van der Meer P,Adriaan AV,Eril L,et al.Erythropoietin in cardiovascular diseases[J].Eur Heart J,2004,25:285-291.
  • 6Moon C,Krawczyk M,Ahn D,et al.Erythropoietin reduces myocardial infarction and left ventricular functional decline after coronary artery ligation in rats[J].Proc Natl Acad Sci USA,2003,100:l1612-l1617.
  • 7Parsa CJ,Kim J,Riel RU,et al.cardioprotective effects of erythropoietin in the reperfused ischemic heart:a potential role for cardiac fibroblasts[J].J Biol Chem,2004,279:20655-20662.
  • 8Hirata A,Minamino T,Asanuma H,et al.Erythropoietin just before reperfusion reduces both lethal arrhythmias and infarct size via the pho-phatidylinositol-3 kinase-dependent pathway in canine hearts[J].Cardiovasc Drugs Ther,2005,19:33-40.
  • 9Lipsic E,van der Meer P,Henning RH,et al.Timing of erythropoietin treatment for cardioprotection in ischemia/reperfusion[J].J Cardiovasc Pharmaco1,2004,44:473-479.
  • 10Xu B,Dong GH,Liu H,et al.Recombinant human erythropoietin pretreatment attenuates myocardial infarct size:a possible mechanism involves heat shock Protein 70 and attenuation of nuclear factor-kappaB[J].Ann Clin Lab Sci,2005,35:161-168.

二级参考文献11

  • 1Curtis MJ , Walker MJA. Quantification of arrhythmias using scoring systems : an examination of seven scores in an in vivo model of regional myocardial ischemia[J]. Cardiovasc Res,1988,22(9):656-665.
  • 2Ravingerov T,Tribulova N,Slezak J et al.Brief , intermediate and prolonged ischemia in the isolated crystalloid perfused rat heart:relationship between susceptibility to arrhythmias and degree of ultrastructural injury[J].J Mol Cell Cardiol,1995,27(9):1937-1951.
  • 3Juul SE, Yachnis AT, Christensen RD. Tissue distribution of erythropoietin and erythropoietin receptor in the developing human fetus[J]. Early Hum Dev,1998, 52(3):235-249.
  • 4Wright GL, Hanlon P, Amin K et al. Erythropoietin receptor expression in adult rat cardiomyocytes is associated with an acute cardioprotective effect for recombinant erythropoietin during ischemia-reperfusion injury[J]. FASEB,2004,18(9):1031-1033.
  • 5Calvillo L, Latini R, Kajstura J et al. Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling[J]. Proc Natl Acad Sci USA, 2003,100(8):4802-4806.
  • 6Tramontano AF, Muniyappa R, Black AD et al. Erythropoietin protects cardiac myocytes from hypoxia-induced apoptosis through an Akt-dependent pathway[J]. Biochem Biophys Res Commun,2003,308(4):990-994.
  • 7Moon C, Krawczyk M, Ahn D et al. Erythropoietin reduces myocardial infarction and left ventricular functional decline after coronary artery ligation in rats[J]. Proc Natl Acad Sci USA,2003,100 (20):11612-11617.
  • 8Yang XP , Liu YH , Peterson E et al . Effect of neutral endopeptidase 24.11 inhibition on myocardial ischemia/reperfusion injury:the role of kinins[J].J Cardiovasc Pharmacol ,1997,29(2) :250-256.
  • 9Brines ML, Ghezzi P, Keenan S et al. Erythropoietin crosses the blood brain barrier to protect against experimental brain injury[J]. Proc Natl Acad Sci USA,2000,97(19):10526-10531.
  • 10Siren AL, Fratelli M, Brines M et al. Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress[J]. Proc Natl Acad Sci USA,2001, 98(7):4044-4049.

共引文献17

同被引文献28

  • 1王砚青,江时森,乐美兆,邱红.促红细胞生成素对大鼠心肌缺血-再灌注损伤的保护作用[J].医学研究生学报,2005,18(4):338-342. 被引量:18
  • 2Kim R J, Judd RM, Chen EL, et al. Relationship of elevated 23Na magnetic resonance image intensity to infarct size after acute reperfused myocardial infarction. Circulation, 1999, 100: 185- 192.
  • 3Cai Z, Manalo D J, Wei G, et al. Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury. Circulation, 2003,108 : 79-85.
  • 4Caiola KJW. USE of erythropoietin in heart failare management[ J]. Ann Phamacother,2004 ,38 :2145 - 2149.
  • 5Van der Meer P, Groenveld HF, Januzzi JL Jr, et al. Erythropoietin treat- ment in patients with chronic heart failure:a meta-analysis [J]. Heart, 2009,95 : 1278 - 1279.
  • 6Zhang J, Wu Y ,Jin Yet al. Intravitreal injection of erythropoietin protects both retinal Vascalar and neuronal ceils in early diabetes [ J ]. Invest Ophthalmol Vis Sci ,2008,49:732 - 42.
  • 7Schmid JA,Birbach A. Ikappa B. Kinase beta(Ikkbeta/Ikkz/IKBKB) -a key molecule in signaling to the transcription factoy NF-Kappab [ J ]. Cytokine Growth Factor Rew, 2008,19 : 157 - 165.
  • 8Yamada M, Burke C, Colditz P, et al. Erythropoietin proteets against apoptosis and increases expression of non - neuronal cell markers in the hypoxia-injured developing brain[ J]. J Pothol,2011,224 : 101 - 199.
  • 9Keogh CL, Yu SP, Wei L. The effect of recombinant human erythropoie- tin on neurovasculature repair after focal ischemic stroke in neonatal rats [ J]. J Pharmacol Exp Ther,2007,322:521 - 528.
  • 10Zhang L, Chopp M, Zhang RL, et al. Erythropoietin amplifies stroke-in- duced digodendrogenesis in the rat[J]. Plos One,2010,5: e11016.

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