二正丁基锡二2-(2-甲氧基-4-甲酰基苯氧基)乙酸酯的合成、晶体结构及杀菌活性

Synthesis,crystal structure and antibacterial activity of the di-n-butyltin di-2-(2-methoxy-4-formylphenoxy)acetic ester

在苯溶液中,将2-(2-甲氧基-4-甲酰基苯氧基)乙酸与二正丁基氧化锡进行脱水反应,获得二正丁基锡二2-(2-甲氧基-4-甲酰基苯氧基)乙酸酯.经过元素分析1、H NMR和IR及晶体结构测定等手段对其进行了结构表征.结果表明该晶体结构属于三斜晶系:Pī空间群;晶胞参数a=1.403 92(12)nm,b=1.694 09(15)nm,c=2.000 93(18)nm,α=112.527 0(10)°,β=96.879(2)°,γ=100.041(2)°,Z=2.合成化合物的中心Sn原子为五配位,构成以Sn为中心,扭曲的三角双锥构型,通过分子间氢键形成一维链状结构.杀菌活性顺序为:标题化合物>二丁基氧化锡>2-(2-甲氧基-4-甲酰基苯氧基)乙酸.

The complex di-n-butyltin di-2-（2-methoxy-4-formylphenoxy）acetic ester（1） was synthesized by the reactions of di-n-butyl tin oxide with 2-（2-methoxy-4-formylphenoxy）acetic acid and azeotropic removal of water with benzene.The compound（1） was characterized by elemental analysis,^1H NMR,FT-IR spectroscopy and single crystal X-ray diffraction analysis.The crystal belongs to space group Pī,the cell parameter are：a=1.403 92（12） nm,b=1.694 09（15） nm,c=2.000 93（18） nm,α=112.527 0（10）°,β=96.879（2）°,γ=100.041（2）°,Z=2.The Sn atoms are considered as five-coordinate and exist as distorted trigonal bipyramidal geometry in a one-dimensional chain. The compound （1） exhibit good antibacterial properties, while the antibacterial properties decrease in the order the compound （1） 〉 di-n-butyltin oxide 〉 2- （2-methoxy-4-formylphenoxy） acetic acid.