冠心病患者外周血内皮祖细胞与LDL-C的相关性分析及意义

The relationship between circulating endothelial progenitor cells and low density lipoprotein-cho-lesterol in coronary artery disease

目的探讨冠心病患者外周血内皮祖细胞（EPCs）与低密度脂蛋白-胆固醇（LDL-C）的关系及临床意义。方法55例经冠状动脉造影证实的冠心病患者（冠心病组）和32例经冠状动脉造影证实的非冠心病患者（对照组），采用流式细胞术分析外周血EPCs，同时检测LDL-C。结果冠心病组外周血EPCs较对照组显著降低，LDL-C较对照组显著升高，差异均有统计学意义（P〈0．01）；冠心病组外周血EPCs与LDL-C呈负相关关系（r=-0.656，P〈0.01）。结论冠心病患者外周血EPCs与LDL-C呈负相关关系，升高的LDL-C是外周血EPCs降低的原因之一，提示提高外周血EPCs可降低LDL-C，减少心血管危险事件的发生。

Objective To study the relationship between circulating endothelial progenitor cells （EPCs） and plasma low density lipoprotein-cholesterol（ LDL-C） in patients with coronary artery dis- ease（CAD）. Methods Circulating EPCs was determinated by flow cytometry assay in 55 patients with CAD（CAD group） and 32 patients without CAD（control group）, and also measured plasma concentration of LDL- C. Results In CAD group, the number of circulating EPCs was （0.033 ±0.014） %, which was much lower than that（0.054 ±0.013） % in control group（ P〈 0.01）. The level of plasma concen-tration of LDL-C was（3.10 ±0.42）mmol/L in CAD group, which was much higher than that （2.63 ±0.43） mmol/L in control group（P 〈 0.01）. The number of circulating EPCs was correlated inversely with plasma concentration of LDL-C in CAD group（ r = -0.656,P 〈 0.01 ）. Conclusion In patients with CAD, higher LDL-C level may be one of the reasons why circulating EPCs is lower.