参附注射液在心肌保护中作用的临床研究

A clinical study on the protective effects of Shenfu injection on ischemia reperfusion injured myocardinm

目的研究在围术期应用参附注射液对体外循环心脏手术所引起的心肌缺血再灌注损伤是否具有保护作用。方法选取32例择期手术的心脏病人,随机分入两组:对照组和参附组。测定术中冠状静脉窦回血中乳酸脱氢酶,肌酸磷酸激酶同工酶MB和肌钙蛋白I的浓度变化。对比研究两组的临床资料和3种酶指标在不同时间点的差异。结果两组病例的临床资料相近。参附组3种指标的浓度在主动脉开放即刻明显高于阻断前,开放后5min与开放即刻没有显著差异。对照组与之相反。两组之间3种指标的浓度只在主动脉开放即刻有显著的组间差异。结论心脏手术围术期应用参附加重心肌的缺血性损伤,但对于减轻再灌注损伤具有一定的作用。

Objective To evaluate the protective effects of perioperative use of Shenfu injection on myocardial isehemia reperfusion injury reduced by cardiac surgery with ardiopulmona. Methods 32 elected patiens were enrolled and randomly divided into two groups ： control group and Shenfu group. The levels of LDH, CK - MB and in coronary sinus blood were measured serially at three time points, before aortic cross clamping, mediately after aortic declamping and 5 minutes after aortic, declamping. The clinical data were compared between groups and the serum levels of three markers were compared between groups or within groups. Results The clinical data of two groups were similar. In Shenfu group, three markers＇levels were significantly higher at the time of aortic declamping than before clamping, and had not significant changes during the early 5 minutes after declamping. Opposite results were observed in control group. Between groups significant differences were observed only at the time of aortic declamping, which of Shenfu injection aggravats myocardial fusion in jury. were significantly higher in Shenfu group. Conclusion：Perioperative use ischemia injury, however, it plays an important role in alleviating reperfusion in jury.