三氯锗取代丙酰氢化噻唑-2-硫酮类化合物及其水解产物的合成

Synthesis of N-(Trichlorpgermyl) Substituted Propionyl Hydrothiazol-2-Thiones Compounds and Their Hydrolysis Products

某些有机锗化物,例如β-羧乙基锗倍半氧化物及其衍生物能诱发干扰素,对癌症有一定疗效,日本专利报道丙酰胺基锗倍半氧化物及其衍生物也具有抗癌活性,白明章等曾合成丙酰芳胺基锗倍半氧化物。 本文由三氯锗取代丙酸Ⅰ_(u-c)与二氯亚硫酰反应得到了三氯锗取代丙酰氯Ⅱ_(a-c)

In this paper trichlorogermyl propionyl chlorides Ⅱ a-c were prepared by the reaction of trichlorogermyl propionic acid Ⅰ a-c with sulfenyl dichloride in 86%-9.1 % yields.The compounds Ⅱ a-c reacted with thiazolidine-2-thione or 2-mercaptobcnzothiazolc to form the N-(trichlorogermyl) substituted propionyl-thiazolidine-2-thione Ⅲ u_cand N-(trichlorogermyl) substituted propionyl benzothiazoline-2-thione IVa-c in 62. 9%-97. 7% yields.The β-substituted propionyl thiazolidine-2-thionyl germanium sesquioxide Va-cand β-substituted propionyl benzothiazoline-2-thionyl germanium sesquioxide VIa-c were obtained by hydrolysis of compounds Ⅲa-c and Ⅲa-c in 44. 0%-83. 8% yields.The compounds Ⅱ b-c, Ⅲa-c, Ⅳa-c, Ⅴa-cand VIa-c are new compounds.