性激素对阉割雄鼠免疫力和生存能力的影响

Effects of sex hormones on living ability and immunological competend in castrated male mouse

切除性腺雄鼠定期接受雌或雄性激素治疗，在１～１８月龄段，经雌二醇治疗的雄鼠平均死亡月龄高于安慰剂组３８％（Ｐ＜０．０１），高于雄激素治疗组６３％（Ｐ＜０．０５）；在１～２１月龄段，经雌二醇和孕酮联合治疗的动物死亡月龄高于雄激素治疗组４６％（Ｐ＜０．０５）。免疫学研究发现，雌二醇可明显提高雄鼠淋巴细胞转化能力（Ｐ＜０．０１）以及腹腔巨噬细胞吞噬能力（Ｐ＜０．００１）。生化研究表明，雌性激素可明显降低雄鼠血中胆固醇含量（Ｐ＜０．０５～０．００５）。结果提示，雌性激素对于延缓衰老具有深远的意义。

The castrated mice were regularly treated with hormonal replacement therapy. During 1 to 18 months period, administration of estradiol produce a 38% increase of the death rate as compared with the control(P<0 01), a 63% increase as compared with the testosterone group (P<0 05); During to 21 month old, the death age of mice treated by both estrodial and progesterone is 46% higher than mices treated with testosterone(P<0 05). Through immunoassay, estrogens can significantly enhanced immunological competence in lymphocyte transformation and in phagocyte phagocytosis. Biochemistry research showed that estrogen can signigicantly reduce the level of blood cholesterol in male mice (P<0 05～0 005). Scientific experiment suggested that estrogen may possess deep effects on delaying senility.