4-溴邻苯二甲酸酐中杂质的高效液相色谱分析

Analysis of Impurities in the 4-Bromophthalic Anhydride Products by High Performance Liquid Chromatography

利用高效液相色谱,外标法定量测定4-溴邻苯二甲酸酐中苯酐、4-溴邻苯二甲酸、4-溴邻苯二甲酸酐等的含量。采用AgillentTC-C18柱,25℃,以甲醇、乙酸水溶液为流动相(体积比60∶40),检测波长为236nm。可通过一次进样在30分钟内完成对样品中主要物质的全面分析。

An analysis method based on High Performance Liquid Chromatography is developed for the composition determining of the products of 4-bromophthalic anhydride process. The main components are as follows ：phthalic anhydride ,phthalic acid ,4-bromophthalic acid ,4-bromophthalic anhydride. The column is Agillent TC-C18 at 25℃, acetic acid aqueous solution and methanol are two mobile phases using elution and the wave length of ultraviolet detection is 236nm ,overall analysis on the four main components of the product can be finished in 30min with one sample transfusion.