摘要
通过分析纤维堆囊菌(Sorangium cellulosum)子实体的性质,子实体提取物的体外抑菌活性,体外肿瘤细胞抑制活性和动物体内毒性及抑瘤活性,探索纤维堆囊菌子实体作为药用菌材料的可行性和药用前景。实验证明,纤维堆囊菌子实体代谢物组成稳定,子实体的提取物对于真菌有显著而广泛的抑制活性,并且对革兰氏阳性细菌也有一定的抑制作用,对于肿瘤细胞如肝癌Bel7402株系具有很强的体外杀伤活性,子实体提取物灌胃对小鼠无毒性反应,并能够明显抑制移植瘤S180的生长。实验结果说明纤维堆囊菌子实体具有作为药用资源的潜力。
By exploring the feasibility of S. cellulosum fruiting bodies as novel medicinal bacterial materials, the anti-microbial activities, anti-tumor effects in vitro and in vivo of the fruiting bodies extracts were determined. The experiments indicate that the extracts of the fruiting bodies have a significant multi-activity to inhibit the growth of fungi and Gram-positive bacteria. The extracts are active on tumor cells, such as Be17402 in vitro and tumor S180 in vivo .The fruiting bodies of S. cellulosum and the extracts from the fruits are rather stable. These findings suggest that the S. cellulosum fruiting bodies are potential medicinal materials which can be used in therapy.
基金
国家自然科学基金资助项目(39870003
30070008)
国家863基金资助项目(2006AA09Z415)
关键词
粘细菌
纤维堆囊菌
子实体
药用菌
myxobacteria
sorangium cellulosura
fmiting body
medicinal bacterial materials
