甘肃省回、汉两民族Apo-E基因多态性与糖尿病的关系

The correlation between genetic polymorphism of Apo-E and diabetes in Muslim and Han populations

本研究在甘肃省回、汉族中共发现了5种基因型,其中包含两个以C和T碱基替换为特征的多态性突变。Apo-E的基因型和基因频率在回、汉族中的差异有统计学意义(P<0·01和P<0·05)。Apo-E的基因型和基因频率在正常对照与糖尿病组之间的差异也有统计学意义(P<0·01)。

The study of genotype and allele of Apo-E in muslim population （n： 19 in normal control, n：28 in T2DM） and Han population （n=38 in NC, n：29 in T2DM） showed that （1） there were five genotypes detected; （2） there were differences in Apo-E genotypes and gene frequency between Muslin and Han populations and between groups of T2DM and normal control （all P〈0.05）.