摘要
为了探索接触低浓度苯的生物监测指标,在建立了灵敏、特异的尿中反,反-粘糠酸(t,t-MA)的高效液相色谱(HPLC)、苯巯基尿酸(S-PMA)的色谱/质谱/质谱(LC/MS/MS)测定方法的基础上,对49位接触低浓度苯的工人及20位非职业接触者进行了生物监测。结果表明:在苯接触浓度低于3.2mg/m3(1ppm)的情况下,作业工人的尿t,t-MA和S-PMA浓度与空气中苯的TWA浓度显著相关;尿酚与空气中苯的TWA浓度之间的相关性很差。吸烟能增加尿t,t-MA和S-PMA的浓度。
The methods for determining urinary t,t muconic acid(t,t MA) by HPLC and S phenylmercapturic acid(S PMA) by LC/MS/MS were developed and successfully applied to urine samples from 49 workers exposed to benzene and 20 non exposed controls.The t,t MA and S PMA concentrations in urine correlate linearly with time weighted average benzene concentration in the breath zone air of workers.When benzene concentration in air was below 3.2 mg/m 3(1 ppm),urinary t,t MA and S PMA were far more specific than phenol.Urinary t,t MA and S PMA can be proposed as suitable indicators for the monitoring of benzene exposure concentrations down to 3.2 mg/m 3 level.
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
1997年第3期134-137,共4页
Chinese Journal of Industrial Hygiene and Occupational Diseases
关键词
粘糠酸
苯巯基尿酸
酚
苯
生物监测
生物标志物
Muconic acid S phenylmercapturic acid Phenol Benzene Biological monitoring Biomarker