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中毒性肝损害发病机制的研究进展 被引量:2

Progress in the Research on Drug/Chemicals-induced Liver Injury
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摘要 中毒性肝损害在临床上十分常见,发病率仅次于病毒性肝炎。本文主要从肝脏对药物(毒物)的代谢、肝损害基本要素以及中毒性肝损害的发病机制研究等方面进行综述,以便于今后临床科研工作。 The incidence of drug/chemicals-induced liver injury is high, second to that of virus hepatitis around the country. The review makes a brief introduction to metabolism of chemicals in liver, hepatocellular apoptosis or necrosis, and some mechanisms involved in liver injury caused by drug/chemicals.
作者 温韬 赵金垣
出处 《环境与职业医学》 CAS 北大核心 2007年第3期350-352,共3页 Journal of Environmental and Occupational Medicine
基金 北京市自然科学基金资助(编号:7063098)
关键词 中毒 肝损害 机制 poisoning liver injury mechanisms
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参考文献17

  • 1LEE W M. Drug-induced hepatotoxicity [ J ]. N Engl J Med, 2003, 349: 474-481.
  • 2LARREY D. Drug-induced liver diseases[ J ]. J Hepatol, 2000, 32: 77-88.
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  • 7HAOUZI D, LEKEHAL M, MOREAU A, et al. P450-generated reactive metabolites cause mitochondrial permeability transition, caspase activation, and apoptosis in rat hepatocytes[ J ]. Hepatology, 2000, 32: 303-311.
  • 8傅青春.中毒性肝损伤的生化和细胞机制[J].肝脏,2002,7(4):264-266. 被引量:7
  • 9HIGUCHI H, GORES GJ. Mechanisms of liver injury: an overview [ J ]. Current Mol Med, 2003, 3 : 483-490.
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二级参考文献2

  • 1Kaplowitz N. Cell death at the millennium:implications for liver diseases. Clin Liver Dis, 2000,4: 1-23.
  • 2Zimmerman H. Hepatotoxicity: The adverse effects of drugs and other chemicals on the liver, 2nd ed. Philadelphia: lippincott Willians & Wilkins: 1999

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