呼吸病区抗菌药物使用量与铜绿假单孢菌耐药的相关性分析

Analysis of the correlation between Consumption of anti-bacterial agents and resistance rate of Pseudomonas aeruginosa in respiratory unit

目的 探讨2004～2006年呼吸病区抗茵药物使用与铜绿假单孢茵（PA）耐药水平变化之问的关系。方法计算12种抗茵药物平均每日每百张床位所消耗的DDDs及同期PA的耐药率，并对抗茵药物用量与耐药率进行相关性分析。结果FEP、CFS、MEM的使用量分别与PV对CIP、LEV、CTX的耐药率呈显著相关性；而LEv的使用量又分别与PV对CFS和IPM的耐药率呈显著相关性。结论呼吸病区FEP、CFS、MEM、LEV的使用量与PA耐药率呈显著相关性。

OBJECTIVE To investigate the relationship between administration of anti-bacterial agents and resistance rate of P. aeruginosa in respiratory unit. METHODS The total antibacterial consumption expressed as defined daily doses （DDD）/ day/100bed, as well as resistance rate of P. aeruginosa were collected, and their correlation was analyzed. RESULTS The analysis revealed a significant positive correlation between the consumption of Cefepime and Cefoperazone-Sulbactam and Meropenem between resistance rate of P. aeruginosa of Ciprofloxacin and Levofloxacin and Cefiazidime, respectively. The analysis revealed a significant positive correlation between the consumption of Levofloxacin between resistance rate of P. aeruginosa of Cefoperazone Sulbactam and Imipenem. CONCLUSION The correlation between the consumption of anti-bacterial agents and resistance rate of Pseudomonas aeruginosa revealed an association in respiratory unit.