2003年福建省部分1～10岁儿童血清HBsAg、抗-HBs调查

Analysis on Positive Rate of HBsAg and Anti-HBs in some Children Aged from One to Ten in Fujian Province in 2003

[目的]了解1-10岁儿童乙型肝炎病毒感染情况与免疫水平,为计划免疫工作的更好开展提供科学依据。[方法]2003年6-7月,在福建省不同类型的13个县(市),抽取1 338名1-10岁儿童血清,检测HBsAg和抗-HBs。[结果]检测1 338名儿童,HBsAg阳性的109人,阳性率为8.15%;抗-HBs阳性的777人,阳性率为58.07%。HBsAg阳性率男性为9.13%,女性为6.91%;抗-HBs阳性率男性为56.09%,女性为60.91%(P>0.05);1-3岁儿童的HB-sAg阳性率明显较低(P<0.01),而抗-HBs阳性率相对较高(P<0.05);HBsAg阳性率接种乙肝疫苗者为7.27%,未接种者为12.54%(P<0.01);抗-HBs阳性率接种者为64.20%,未接种者为44.22%(P<0.01)。HBsAg阳性率山区为7.86%,沿海为8.40%(P>0.05);抗-HBs阳性率山区为57.08%,沿海为58.97%(P>0.05)。HBsAg阳性率城区为4.32%,农村为9.87%(P<0.01);抗-HBs阳性率城区为70.43%,农村为52.49%(P<0.01)。[结论]福建省1-10岁儿童HBsAg阳性率较高,应加强农村儿童乙肝疫苗接种工作。

[Objective]To investigate the infection rates and immunity of hepatitis B virus in some children aged from 1 to 10 in Fujian province in order to provide scientific basis for immunity planning. [Methods]1338 children were selected from different areas in Fujian from June to July in 2003. ELISA was used to detect HBsAg and anti-HBs for them. [Results]Among the children,8. 15G was HBsAg positive and 58.07% was anti-HBs positive. Positive rate of HBsAg in boys was 9.13% ,which had not significant difference compared with 6.91% in girls （ P〉0.05）. Positive rates of anti-HBs in boys and girls were 56.09G and 60.91G respectively （ P〉0. 05）. The positive rate of HBsAg among those aged from one to three was significantly lower than others,and anti-HBs was higher than others. Positive rates of HBsAg and anti- HBs in the children who were inoculated against the hepatitis B virus were 7.27%% and 64.20%. Positive rates of HBsAg and anti-HBs in the children who weren＇t inoculated against the hepatitis B virus were12.54 %and44.22 % （ P〈0.01）. Positive rates of HBsAg among children lived at the mountain village and the coastal city were 7.86% and 8.04% （ P〉0. 05） ,the positive rates of anti-HBs among those 2 groups were 57.08% and 58.97%（ P〉0.05）. Positive rate of HBsAg among children lived at the urban and the rural children were 4.32% and 9.87% （ P〈0.01） ,the positive rates of anti-HBs among those 2 groups were 70.43% and 52.49%%（ P〈0.01）. [Conclusion]The positive rate of HBsAg among children aged from 1 to 10 was still high in Fujian, so the hepatitis B vaccines protective inoculation in rural children should be strengthened.