抗高血压药物对自发性高血压大鼠降压及逆转左室肥厚作用

Blood Pressure dependent Effects of Different Antihypertensive Drugs on Regression of Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats

使用４种抗高血压药物治疗自发性高血压大鼠（ＳＨＲ），探讨血压和左室肥厚之间的关系。方法ＳＨＲ４２只雌性，周龄１６周，随机分为６组：（１）高血压基础对照组，在１６周时处死观察有关指标，（２）高血压对照组，（３）卡托普利组（１００ｍｇ／ｋｇ·ｄ－１，（４）培哚普利组（５ｍｇ／ｋｇ·ｄ－１），（５）双氢克尿塞组（１００ｍｇ／ｋｇ·ｄ－１），（６）普萘洛尔组（４０ｍｇ／ｋｇ·ｄ－１），给药１６周，观察血压及左心室肥厚变化。结果抗高血压药物均能明显降低血压，并使左心室肥厚得到抑制，但对ＳＨＲ的体重影响不大。血压与ＬＶＭ／ＢＷ的相关性为ｒ＝０．６４，Ｐ＜０．０５。结论血压升高是左心室肥厚的主要原因之一，因而只要降压药不造成降压的同时反射性地交感兴奋，就能通过降低血压减轻并可逆转左心室肥厚。

Objective\ To study the complicated relationship between blood pressure lowering effect and the regression of left ventricular hypertrophy induced by different types of antihypertensive drugs.\ Methods\ Spontaneously hypertensive rats(SHR) at 16 weeks old after establishment of hypertension were treated with captopril,perindopril,high dose of dihydrothiazide,as well as β blocker propranolol for 16 wks. Age matched untreated SHR and normotensive Wistar Koyto rats(WKY) served as control. Systolic blood pressure was monitored by non invasive tail cuff technique.\ Results\ It was found that blood pressure was significantly lowered after 16 weeks treatment in all of the 4 treated groups accompained by significant prevention of left ventricular hypertrophy as compared to untreated SHR.\ There was a close correlation between systolic blood pressure and LVM/BW,suggesting that blood pressure per se is an important determinant of left ventricular hypertrophy.\ Conclusion\ It is thus concluded that effect of different antihypertensive drug on regression of left ventricular hypertrophy is mainly blood pressure lowering dependent.