克拉玛依市部分人群乙型肝炎疫苗免疫效果调查

Observation on Immune Effect of Hepatitis B Vaccine among some Population in Karamay

[目的]了解乙型肝炎(乙肝)疫苗对不同人群的免疫效果。[方法]2005年8-10月,在克拉玛依市选取7个计划免疫接种门诊,对237名血清乙肝病毒(HBV)感染指标全部阴性身体健康者,按0、1、6个月程序接种乙肝疫苗,接种后的1-3个月测定血清抗-HBs。[结果]抗-HBs阳转率为77.22%。抗-HBs阳转率<1岁为87.50%,1-17岁为76.19%,18岁以上为70.79%(P>0.05)。标化抗-HBs阳转率女性为81.12%,男性为65.30%(P<0.01);O型血者为74.45%,A型者为79.07%,B型者为71.16%,AB型者为46.70%(P>0.05)。[结论]乙肝疫苗对健康人群有较好的免疫效果,抗-HBs阳转率的高低与血型无关。

[Objective]To understand immune effect of Hepatitis B vaccine among different population, [Methods]237 healthy persons with serum HBV negative were vaccinated with Hepatitis B vaccine in seven programmed immunization clinics from August to October in 2005, for three doses at an interval of zero,one and six months, respectively. Serum anti- HBs was tested in one to three months after accomplishing inoculation. [Results]Positive rate of anti-HBs was 77.22 % in 237 inoculators. Positive rate of anti-HBs was 87.50% in group aged under one year,it was 76. 19% in group aged from one to seventeen years,70.79 % in group aged over eighteen（ P 〈0.05）. Standardized positive rate of anti-HBs in female （81.12%） was higher than that in male （65.30%） （ P 〈0.01）. Standardized positive rate of anti-HBs was 74.45% in people whose blood-group were 0,79.070% in the people with A blood group,71.16 % in the people with B blood group, 46. 70% in the people with AB blood group （ P 〉0.05）. [Conclusion]Immune effect of Hepatitis B vaccine is good for healthy people. Anti HBs positive rate had no relation with blood group.