静脉注射咪唑安定后的脑电效应

Electroencephalography(EEG) Effect in 8 Volunteers After Infusion of 15 mg Midazolam

应用脑电信号定量分析的计算机软硬件技术研究了８位健康志愿者应用咪唑安定后的脑电变化情况。应用非周期性波谱分析方法对用药后１～３Ｈｚ、４～７Ｈｚ、８～１１Ｈｚ和１２～３０Ｈｚ脑电变化情况作了分析，并与描记脑电图作了比较。分析结果表明１２～３０Ｈｚ每秒波数的变化最具规律性，适合作为咪唑安定的药效指标。

The electroencephalographic (EEG) changes in 8 volunteers after infusion of 15 mg midazolam were analysed quantitatively with the computer EEG analysis hardware and software made by authors.The changes of the total number of waves per second and total voltage per second following in 1￣3,4￣7,8￣11and 12￣30 Hz frequency bands derived from aperiodic analysis were compared with those of tracing EEG. The results showed that the total number of waves per second following in 12￣30 Hz band had the characteristic of being an ideal pharmacological indicator.The success of finding such a parameter reflecting the EEG effect makes it possible to study the concentration effect relationship of midazolam.