苯妥英在兔骨折愈合中的作用

THE EFFECT OF PHENYTOIN IN HEALING OF FRACTURE OF RABBITS/

为了观察苯妥英在骨折愈合中的作用，选用健康家兔７２只，手术造成双侧桡骨骨折模型。随机分为三组：全身用药组，局部用药组及对照组。分别于骨折后第９，１６及３０ｄ处死动物，采用Ｘ线摄片、骨痂重量测定及组织学检查等方法观察苯妥英局部应用和全身应用在促进骨折愈合中的作用。结果表明：苯妥英局部应用和全身应用均有促进骨折愈合的作用。

It was reported that the systemic use of phenytoin could promote healing of fracture. In order to observe the effect of local application of phenytoin in the healing of fracture, the experiment was performed. Seventy two rabbits were divided into three groups. Fractures were created on both radius of all rabbits. Group 1, intraperitoneal injection of phenytoin with a dosage of 50 mg/kg per day; Group 2, local use of phenytoin with a dosage of 40 mg/kg was injected in the fracture site every seventy two hours, and Group 3, injection mormal saline of in the control group. Eight rabbits in each group were sacrificed in the 9th, 16th and 30th days after operation respectively. By X ray excuiualtion, the healing of fracture was observed. Dry and wet weights of the callus were detemined. After HE and Mallorys stain, the samples were examined under microscope. Results showed that both local and systemic use of phenytoin promoted healing of fracture. The effects of phenytoin in the two groups were the same and had no significant difference.