趋化因子对肿瘤生长的影响

Effects of Chemokines on Cancer

虽然趋化因子早先被认为主要影响炎症和造血过程时白细胞的迁移,但现在有大量的事实显示它们也影响许多肿瘤过程,像白细胞浸润、血管生成、肿瘤细胞生长、存活、浸润和转移。控制肿瘤细胞内趋化因子网将为肿瘤治疗提供一种选择。

Although chemokines have been thought of primarily as controlling leukocyte trafficking in inflammation and hematopoiesis, there is now accumulating evidence indicates that they are also involved in a number of tumor-related processes, such as the leukocyte infiltrate, angiogenesis, tumor cell growth, survival, invasion, and metastasis. Manipulation of the tumor chemokine network could have therapeutic potential in cancers.