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NBS1在DNA断裂损伤反应和维持端粒稳定中的作用 被引量：5

The Role of NBS1 in DNA Double Strand Break Damage Response and Telomere Stability
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摘要 NBS1作为MRE11/RAD50/NBS1复合物的组分之一,是细胞应答DNA损伤的一个关键蛋白质,在DNA双链断裂修复和维持基因组稳定中发挥重要的作用。端粒是染色体末端由DNA重复序列和蛋白质构成的复合体,其独特结构与DNA双链断裂非常相似。最近几年的研究发现NBS1与端粒也有着十分密切的联系。综述了NBS1在DNA损伤反应中的作用,并探讨NBS1参与维持端粒稳定中的分子机制。 The NBS1 is a component of the MRE11/RAD50/NBS 1 complex （MRN） and plays a critical role in the DNA double strand break （DSB） repair and the maintenance of chromosomal integrity. The telomere is a unique chromosomal structure consisting of repetitive DNA sequences bound by protein complexes, which is similar with DSB. The mechanisms of NBS1 in DNA damage response and maintenance of telomere stability are reviewed in this paper.
作者 罗浩虹 陈瑞川 李程
机构地区 厦门大学生命科学学院细胞生物学与肿瘤细胞工程教育部重点实验室
出处 《细胞生物学杂志》 CSCD 2007年第3期351-355,共5页 Chinese Journal of Cell Biology
基金 福建省自然科学基金资助项目(No.C0210005)
关键词 NBS1 端粒 DNA损伤 NBS 1 telomere DNA damage
分类号 R596.1 [医药卫生—内科学]
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参考文献45

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同被引文献33

  • 1Ying Zhang,Junqing Zhou,Chang UK Lim.The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control[J].Cell Research,2006,16(1):45-54. 被引量：14
  • 2Kobayashi J, Antoccia A, Tauehi H, et al. NBS1 and its functional role in the DNA damage response [J]. DNA Repair (Amst), 2004,3 (8-9) :855-861.
  • 3Robison JG, Lu L, Dixon K, et al. DNA Lesion-specific Co-localization of the Mrell/Rad50/Nbs1 (MRN) Complex and Replication Protein A (RPA) to Repair Foci [J]. Biol Chem, 2005,280(13): 12927-12934.
  • 4Frappart P O, Tong W M, Demuth I, et al. An essential function for NBS1 in the prevention of ataxia and eerebellar defects [J]. Nat Med, 2005,11 (5):538-544.
  • 5Yang Y G, Frappart P O, Frappart L, et al. A novel function of DNA repair molecule Nbsl in terminal differentiation of the lens fibre cells and cataractogenesis [J]. DNA Repair, 2006,5(8):885-893.
  • 6Digweed M, Sperlling K. Nijmegen breakage syndrone: clinical manifestation of defective response to DNA double-strand breaks [J]. DNA Repair (Amst), 2004,3(8-9) : 1207-1217.
  • 7Frappart P O, Tong W M, Demuth I, et al. An essential function for Nijmegen Breakage Syndrome gene (NBS1) and DNA damage response in the prevention of ataxia and cerebellar defects[J]. Nat Med, 2005,11 (5) :538-544.
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  • 10Abner C W, McKinnon P J. The DNA double-strand break response in the nervous system [J]. DNA Repair, 2004, 3 (9): 1141-1147.

引证文献5

二级引证文献3

细胞生物学杂志
2007年 第3期

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