^(99m) Tc-P357血栓显像诊断急性肺栓塞的初步临床研究

Preliminary clinical study of acute pulmonary embolism with 99m Tc P357

为评价９９ｍＴｃＰ３５７血栓显像对急性肺栓塞的诊断价值及其安全性，对７例疑有急性肺动脉血栓栓塞的患者，经静脉注射９９ｍＴｃＰ３５７，１和２小时后行肺平面及断层显像，并与９９ｍＴｃ大颗粒聚合白蛋白肺灌注显像、肺动脉造影、超高速ＣＴ、ＤＳＡ和螺旋ＣＴ对比。结果：４例急性肺栓塞中３例９９ｍＴｃＰ３５７血栓显像阳性，１例溶栓后１个月血栓显像为阴性；另外３例显像结果为阴性，临床诊断分别为慢性肺栓塞、肺血管炎和高血压。初步临床研究表明，９９ｍＴｃＰ３５７对急性肺栓塞的诊断有较大价值。

PURPOSE 99m Tc labeled P357 specially binding to the GPⅡB/ⅢA receptor of activated platelet was studied in acute pulmonary embolism (PE)patients for its safety and diagnostic value METHODS 7 patients with clinically suspected acute PE were studied with 555～740MBq 99m Tc P357 and using planar and tomographic imaging at 1 and 2 hr RESULTS In three of the four patients with acute PE, multiple focal accumulation of P357 in both lungs was observed The positive results were demonstrated by either pulmonary angiogarphy or ultra fast CT And there was significant improvement after thrombolysis 99m Tc P357 imaging was performed in another PE patient only after thrombolysis and there was no accumulation of 99m Tc P357 in lungs to be found In 3 other patients, 99m Tc P357 imaging was negative, with their clinical diagnosis of chronic PE, pulmonary angitis and hypertension respectively CONCLUSIONS The preliminary clinical study showed 99m Tc P357 may be a potential agent for specific identification of acute PE