心肌摄取^(131)I-MIBG的影响因素

Factors influencing the myocardial uptake of MIBG

为了解影响心肌摄取１３１Ｉ间位碘代苄胍（ＭＩＢＧ）的因素，研究了鼠心肌对不同比活度ＭＩＢＧ和使用部分血管活性药物后的摄取及清除，同时对１６例正常人和４９例心肌疾病、４例非心肌疾病患者用不同比活度１３１ＩＭＩＢＧ行心肌显像。结果：鼠心肌在延迟相（４小时以后）对高比活度的ＭＩＢＧ摄取明显大于低比活度的ＭＩＢＧ，并得到临床初步研究证实；在不同时相，血管活性药物心得安（２４小时）、多巴胺（１小时）和多巴酚丁胺（４小时）均对鼠心肌清除ＭＩＢＧ有影响。因此，ＭＩＢＧ比活度、心血管活性药物和部分非心肌疾病均能影响心肌对ＭＩＢＧ的摄取和清除，在应用中应排除上述干扰。

PURPOSE To study the factors influencing myocardial uptake of MIBG METHODS The uptake and clearance of 131 I MIBG were studied in rat myocardium with various specific activity (SA) of MIBG and several vascular active drugs 131 I MIBG myocardial imaging was performed in 16 normals and 53 patients with various SA of 131 I MIBG RESULTS ①Myocardial uptake was greater in high SA MIBG than in low one ②Dobutamine, dopamine and propranolol can affect the myocardial uptake of MIBG in different phases ③Cardiopathy and pheochromocytoma can decrease the uptake of MIBG CONCLUSIONS SA of MIBG, vascular active drugs and partial non cardiopathy may affect the myocardial uptake of MIBG Thereby, we should rule out these factors during 131 I MIBG myocardial imaging