血清肌红蛋白和β2-微球蛋白测定对慢性心力衰竭患者肾功能损害的评价

Serum myoglobin and beta-2-microglobulin in chronic heart failure

目的探讨血清肌红蛋白(Mb)和β2-微球蛋白(β2-MG)对慢性心力衰竭(CHF)患者肾功能损害的评价及其临床意义。方法用放射免疫法测定了120例CHF患者和40例对照组的血清Mb和β2-MG水平,生化法测定血肌酐(Cr)和尿素氮(BUN),并进行对照统计分析。结果CHF组血清Mb、β2-MG、Cr和BUN水平均显著高于对照组,分别为t=9.403,P<0.01;t=10.48,P<0.01;t=2.290,P<0.05;t=2.698,P<0.05,Mb和β2-MG相互间呈正相关(P<0.01),且均与Cr水平呈正相关(P<0.01)。在Ⅱ、Ⅲ、Ⅳ级组间,血清Mb、β2-MG、Cr和BUN水平均依次递增(方差F检验:F=9.180,P<0.01;F=12.39,P<0.01;F=5.048,P<0.05;F=6.429,P<0.05),住院死亡组血清Mb和β2-MG水平显著高于好转出院组(t=2.620,t=3.000.P<0.05)。结论CHF患者血清Mb和β2-MG、Cr和BUN水平显著升高,Mb与β2-MG相互成正相关,且均与Cr相关,住院死亡组Mb和β2-MG水平升高更显著。

Objective To investigate the changes of serum myoglobin （Mb） and beta - 2 - microglobulin （ 132 - MG） in patients of chronic heart failure（CHF）. Methods Serum Mb and 132 - MG were studied in 120 cases of CHF by radioimmunoassay ,40 no CHF patients were served as controls. Results Serum Mb, 132 - MG, Cr and BUN were increased significantly in CHF patients compared with that in the control group（ t = 9. 403, P 〈 0.01 ; t = 10.48, P 〈 0.01 ; t = 2. 290, P 〈 0.05 ; t = 2. 698, P 〈 0.05 ） , the serum Mb level was positively significantly correlated with the serum 132 - MG level（ r = 0. 552, P 〈 0.01 ）. And both were positively significantly correlated with the blood Cr level （ r = 0. 471, r = 0.511, P 〈 0.01 ）. The difference in the mean Mb, 132 - MG, Cr and BUN levels were significantly in different stages （ stage Ⅱ , Ⅲ and Ⅳ respective ） CHF patients （F = 9. 180, P 〈0.01; F =12.39, P 〈0.01; F =5.048, P 〈0.05;F =6.429,P 〈0.05）. In died patients,the Mb and 132 - MG were significantly higher than in no - died patients（ t =2. 620, t =3.000. P 〈0.05）. Conclusion Mb,132 - MG,Cr and BUN were increased in CHF patuents,and markedly decrease in higher stage patients and in died patients. There were positively significantly correlated among the Mb and 132 - MG and Cr.