慢性阻塞性肺病多排螺旋CT灌注成像的初步研究

Elementary investigation of chronic obstructive pulmonary disease with multi-slice CT per-fusion imaging

目的:研究CT灌注成像对慢性阻塞性肺病(COPD)的诊断价值。方法:通过20例志愿者和20例COPD患者的多排螺旋CT灌注成像,采用8排螺旋CT灌注成像,扫描方式为cine(电影扫描),层厚5mm/1i,扫描时间为0.5s/层,延时5s,总扫描时间为45s,欧乃派克(300mg/ml)60ml用高压注射器以4ml/s的流速率通过肘前静脉注入。CT perfusion3软件分析测量兴趣域血流量、血容量、平均通过时间及表面通透性和时间-密度曲线。结果:COPD患者的时间-密度曲线较志愿者曲线平坦,峰值明显降低。COPD患者血流量、血容量及表面通透性明显低于志愿者,具有统计学意义(P<0.05)。结论:多排螺旋CT肺灌注扫描对COPD的诊断有一定的辅助作用。

Objective：To evaluate the diagnosis of CT perfusion in chronic obstructive pulmonary disease （COPD）. Methods： Twenty volunteers and 20 COPD sufferers underwent MSCT perfusion imaging. Cine scan slice with thickness 5 mm/li were processed by 8-row detector spiral CT. Scan time was 0.5 s per circle, delay of time 5 s, and overall scan time was 45 s. Omnipaque （300 mg/ml） was administered at a rate of 4 ml/s from forearm superficial vein for a total of 60 ml by high pressure injector. The data were transferred to a workstation and analyzed by a CT perfusion 3 software, automatically generating a time-density curve and pseudo-color map. Interest district blood flow, blood volume, mean transit time and permeability surface were measured. Results： Time-density curve of COPD patients was flatter than that of the volunteers, and peak height was obviously lower. The COPD sufferers＇ blood flow, blood volume and permeability surface were obviously lower than the volunteers＇, which had statistical significance（P 〈 0.05）. Conclusion：MSCT perfusion is helpful to the diagnosis of COPD.