侵袭性非霍奇金淋巴瘤预后相关因素分析

Prognostic factors of invasive non-Hodgkin's lymphoma

目的研究探讨侵袭性非霍奇金淋巴瘤的预后影响因素。方法回顾性分析137例侵袭性非霍奇金淋巴瘤的临床特征,结合随访资料,应用SPSS 10.0统计软件进行生存分析,并对其预后影响因素进行多因素分析。结果放化疗后达CR者35例(25.5%),其中近期CR 31例(22.6%), PR 67例(48.9%),SD 6例(4.3%),PD 29例(21.2%),总有效率为74.5%。4年总生存率为70.8%,4年无复发生存率为42.7%。Cox模型多因素分析显示,临床分期为Ⅲ～Ⅳ期、PS评分≥2分、累及淋巴结外病变数≥2个与预后关系密切,具有统计学意义。结论侵袭性非霍奇金淋巴瘤通过放化疗综合治疗,生存率有了较大提高。对于不同类型的NHL如何实施个体化的治疗方案,仍需进一步探讨。

Objective There is heterogeneity in non-Hodgkin＇s lymphoma. The purpose of this study is to investigate the prognostic factors of invasive non-Hodgkin＇s lymphoma. Methods From June 2002 to June 2006, 137 patients with invasive non-Hodgkin＇s lymphoma were treated by regular regimen consisting of radiotherapy and chemotherapy. The clinical data including prognostic factors was analyzed by SPSS 10.0. Results After treated with chemotherapy and radiotherapy, 35 （ 25.5% ） patients achieved CR, 67（48.9% ） PR, 6（4.3% ） SD,29（21.2% ） PD, ORR （ objective response rate） of this series was 74.5% o The overall 4-year survival rate was 70. 8%. The PFS （prognosis free survival ） was 42.7%. Multivariate analysis using Cox model indicated that clinical stage Ⅲ-Ⅳ, PS score ≥ 2, more than 2 external nodal involvement were closely correlated with overall survival. Conclusion The overall survival of invasive non-Hodgkin＇s lymphoma treated with present combined therapy regimen has been improved greatly. However, further investigation is still needed for exploring more effective individualized treatment regimen.