中线T细胞淋巴瘤的临床病理、免疫组织化学与形态定量分析

A CLINICOPATHOLOGICAL IMMUNOHISTOCHEMICAL AND CYTOMORPHOMETRIC STUDY ON MIDLINE T CELL LYMPHOMA

应用系列抗体对１２２例中线恶网作免疫组化染色，证实１１２例为Ｔ细胞源性，４例Ｂ细胞性，余６例尚不能分类，支持本病大多数是Ｔ细胞淋巴瘤的观点。本病可分为肉瘤样型和肉芽肿样型两种组织学类型，经形态定量发现前者光镜下可再分为大、中、小细胞亚型。对随访病例作临床病理分析表明，不同组织类型者其临床表现有所不同并与其预后密切相关。

One hundred and twenty two cases of midline malignant reticulosis (MMR) were studied. A series of antibodies including anti LCA, UCHL 1, L26,CD45R, and anti lysozyme were used on paraffin sections by ABC and PAP methods. The results were as follows: 112 cases exhibiting T cell origin, 4 cases showing B cell origin, and 6 cases being of uncertain lineage. This result is in accordance with the point of view that most of MMR are T cell lymphoma. Two histological types were classified: sarcomatoid type and granulomatoid type. By using image analyzer, the sarcomatoid type was subdivided into small, medium and large cell types. Sixty two cases with follow up data were collected for clinicopathologic analysis. One year and five year survival rates in cases with different histologic types were compared and statistically analysed. The results showed that the prognosis was closely related to the histological type.