脑卒中患者使用甘露醇前后早期肾功能的变化

CHANGES OF EARLY RENAL FUNCTION BEFORE AND AFTER USING MANNITOL IN PATIENTS WITH CEREBRAL APOPLEXY

观察脑卒中患者２０例使用甘露醇前后早期肾功能变化，以了解甘露醇的肾毒性作用。结果显示，使用甘露醇后，血清肌酐、尿素氮较治疗前呈上升趋势，但其差异无显著性（Ｐ＞０．０５），而血和尿中β２微球蛋白（β２－ＭＧ），α１使用微球蛋白（α１－ＭＧ），尿ＮＡＧ，γ－ＧＴ在使用甘露醇５～１０天后有明显上升（Ｐ＞０．０５），证明甘露醇有一定肾毒性作用。血和尿α１－ＭＧ，β２－ＭＧ，尿ＮＡＧ，ｒ－ＧＴ能灵敏反映早期甘露醇肾损害。

The alteration of renal function after initiation of mannitol infusion were monitored in 20 patients with cerebrovascular accident to evaluate whether mannitol has nephrotoxicity effects. Serum creatinine and urea nitrogen were increased after initiation of mannitol infusion, but hadn't reached stagistical significance. Urinary and serum α 1 microglobulin, β 2 microglobulin and urinary NAG, γ GT were significantly increased after 5～10 days successive infusion of mannitol ( P <0.05). The results suggest that the acute nephrotoxicity effect of mannitol should not be ignored.