异丙酚在妇科腹腔镜手术中预防恶心呕吐的疗效观察

Effect of Antiemetic Propofol on Postoperative Nausea and Vomitting

目的评价异丙酚预防妇科腹腔镜手术术后恶心呕吐的效果。本研究通过对70例择期腹腔镜下妇科手术患者的观察,了解其对术后恶心呕吐的预防作用。方法70例ASAI^II级择期腹腔镜下妇科手术患者,随机分为实验组和对照组,实验组在麻醉苏醒后静脉注入异丙酚0.4mg/kg,对照组使用生理盐水2ml。观察麻醉苏醒后24h内两组患者恶心呕吐的发生率。结果实验组在麻醉清醒后24h内恶心呕吐发生率(54.3%)明显低于对照组(74.3%),P<0.05。结论亚催眠量的异丙酚用于预防术后恶心呕吐有一定的疗效。

Objective To evaluate the effect of propofol in preventing patients from nausea and vomit which were caused by performing the operation of gynecological laparoscopy. 70 patients with surgery of gynecological laparoscopy were involved in this study,and the effect of antie-metic propofol on PONV was observed. Methods 70 ASA grade Ⅰ- Ⅱ patients were randomly divided into 2 groups. Propofol group and control group 0.4 mg/kg propofol was administrated intravenous when the patient was awaken from an esthesia,as to the control group, 2 mL saline was administrated as placebo. PONV was recorded in the 24 hrs after surgery. Results Nausea and vomit in the propofol group was 54.3% in 24hrs,,it was significantly lower than the control group （74.3%）, P 〈 0.05. Conclusions Antiemetic propofol can depress the PONV,but further studies are demanded.