摘要
本研究运用竞争性放射免疫分析法,对40名健康成人,58例单纯性肥胖患者和23例经病理证实的库欣综合症患者进行唾液皮质醇测定,发现单次午夜唾液皮质醇测定诊断库欣综合征的敏感性和特异性可达100.0%和91.4%,提示唾液皮质醇检测是一种高诊断价值的无创性检查方法,可作为库欣综合征的首选筛查指标。
A total of 121 subjects comprising 40 normal subjects, 58 patients with overweight or obesity and 23 patients with Cushing＇s syndrome were recruited in the study. The modified radioimmunoassay （RIA） for salivary cortisol test was established and its normal range was determined. Then the diagnostic value of the salivary cortisol for the initial diagnosis of Cushing＇s syndrome was evaluated and single midnight salivary cortisol test demonstrated a sensitivity of 100.0% and specificity of 91.4 %. Salivary cortisol test can be recommended as a first-line diagnostic parameter for Cushing＇s syndrome.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2007年第3期256-257,共2页
Chinese Journal of Endocrinology and Metabolism
基金
国家科技攻关计划(基金编号2004BA720A29)
