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黄芪多糖影响NOD小鼠胰岛超微结构及胰腺Th1/Th2型细胞因子表达 被引量：13

Astragalus polysaccharides influence ultrastructure of islets and Th1/Th2 cvtokine gene expression of pancrease in NOD mice
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摘要 探讨黄芪多糖(APS)对1型糖尿病的影响。电镜观察NOD小鼠胰岛超微结构,RT-PCR检测胰腺Th1/Th2型细胞因子表达。APS组胰岛超微结构保存完好,Th1型细胞因子表达下调,Th2型细胞因子表达上调。APS可纠正1型糖尿病的细胞因子免疫失衡。 The effects of astragalus polysaccharide （APS） on type 1 diabetes mellitus were investigated. The mRNA expressions of Th1/Th2 cytokines of pancrease and ultrastructure of islet were studied. Uhrastructure of islets was well protected in APS group ; the mRNA expressions of Th1 cytokines were downregulated and those of Th2 cytokines were upregulated in APS group. APS may correct the imbalance of Th1/Th2 cytokines.
作者 陈蔚 李益明 俞茂华
机构地区 复旦大学附属华山医院老年科 复旦大学附属华山医院内分泌科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2007年第3期269-271,共3页 Chinese Journal of Endocrinology and Metabolism
基金 上海市卫生局中医药科研基金(No:982029)
关键词 黄芪多糖 糖尿病 1型 细胞因子类 Astragalan Diabetes mellitus, type 1 Cytokines
分类号 R285.5 [医药卫生—中药学]
  • 相关文献

参考文献10

  • 1陈蔚 俞茂华.黄芪多糖的免疫调节作用[J].中外实用医学杂志,2000,2(10):1-3.
  • 2陈蔚,刘芳,俞茂华,朱秋毓,朱禧星.黄芪多糖对NOD小鼠1型糖尿病的预防作用[J].复旦学报（医学版）,2001,28(1):57-60. 被引量：34
  • 3陈蔚,俞茂华.以基因芯片技术研究黄芪多糖对NOD小鼠胰岛基因表达的影响[J].中华内分泌代谢杂志,2004,20(6):545-548. 被引量：16
  • 4Hill NJ, Van Gunst K, Sarvetnick N. Th1 and Th2 pancreatic inflammation differentially affects homing of islet-reactive CD4 cells in nonobese diabetic mice. J Immunol, 2003,170 : 1649-1658.
  • 5Koarada S, Wu Y, Olshansky G, et al. Increased nonobese diabetic Th1:Th2 (IFN-gamma: IL-4) ratio is CD4^+ T cell intrinsic and independent of APC genetic background. J Immunol, 2002,169:6580- 6587.
  • 6Sparre T, Christensen UB, Mose Larsen P, et al. IL-1beta induced protein changes in diabetes prone BB rat islets of Langerhans identified by proteome analysis. Diabetologia, 2002,45 : 1550-1561 .
  • 7Ventura-Oliveira D, Vilella CA, Zanin ME, et al. Kinetics of TNFalpha and IFN-gamma mRNA expression in islets and spleen of NOD mice. Braz J Med Biol Res, 2002, 35:1347-1355.
  • 8Grewal IS, Grewal KD, Wong FS, et al. Expression of transgene encoded TGF-beta in islets prevents autoimmune diabetes in NOD mice by a local mechanism. J Autoimmun, 2002,19:9-22.
  • 9Glowacka E, Banasik M, Lewkowicz P, et al. The effect of LPS on neutrophils from patients with high risk of type 1 diabetes mellitus in relation to IL-8, IL-10 and IL-12 production and apoptosis in vitro. Scand J Immunol, 2002,55:210-217.
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二级参考文献25

  • 1赵克胜,丁丽轩,孔海燕,田淑媛,金伯泉,刘雪松.黄芪多糖增强人外周血单个核细胞产生肿瘤坏死因子的研究[J].中国中西医结合杂志,1993,13(5):263-265. 被引量：34
  • 2Liu J, Beller DI. Distinct pathways for NF-kappa B regulation are associated with aberrant macrophage IL-12 production in lupus- and diabetes-prone mouse strains. J Immunol, 2003,170:4489-4496.
  • 3Hill NJ, Van Gunst K, Sarvetnick N. Th1 and Th2 pancreatic inflammation differentially affects homing of islet- reactive CD4 cells in nonobese diabetic mice. J Immunol, 2003,170:1649-1658.
  • 4Zhang YC, Pileggi A, Agarwal A, et al, Adeno-associated virusmediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice. Diabetes, 2003,52:708-716.
  • 5Rajagopalan G, Kudva YC, Flavell RA, et al. Accelerated diabetes in rat insulin promoter-tumor necrosis factor-alpha transgenic nonobese diabetic mice lacking major histocompatibility class Ⅱ molecules.Diabetes, 2003,52:342-347.
  • 6Zhou W, Zhang F, Aune TM. Either IL-2 or IL-12 is sufficient to direct Th1 differentiation by nonobese diabetic T cells. J Immunol,2003,170:735-740.
  • 7Koarada S, Wu Y, Olshansky G, et al. Increased nonobese diabetic Th1:Th2 ( IFN-gamma: IL-4) ratio is CD4 + T cell intrinsic and independent of APC genetic background. J Immunol, 2002,169:6580-6587.
  • 8Sparre T, Christensen UB, Mose Larsen P, et al. IL-1beta induced protein changes in diabetes prone BB rat islets of Langerhans identified by proteome analysis. Diabetologia, 2002 ;45:1550-1561.
  • 9Ventura-Oliveira D, Vilella CA, Zanin ME, et al. Kinetics of TNFalpha and IFN-gamma mRNA expression in islets and spleen of NOD mice. Braz J Med Biol Res, 2002,35:1347-1355.
  • 10Quintana FJ, Carmi P, Cohen IR. DNA vaccination with heat shock protein 60 inhibits cyclophosphamide-accelerated diabetes. J Immunol,2002; 169:6030-6035.

共引文献47

同被引文献165

引证文献13

二级引证文献400

中华内分泌代谢杂志
2007年 第3期

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