摘要
内脂素(visfatin)是新近发现的一种脂肪因子,具有类似胰岛素的作用。本研究显示,长期高脂喂养大鼠内脂素的表达与肥胖和胰岛素抵抗相平行。阻断肾素血管紧张素系统后,内脂素表达降低,胰岛素抵抗现象改善。内脂素可能在胰岛素抵抗的发生中起重要作用。
Visfatin was recently reported as an adipokine and was found to exert insulin-mimicking effects. The results showed that the expression of visfatin parallelled with obesity and insulin resistance in long term high fat chow-fed rats. The expression of visfatin mRNA was decreased and the insulin resistance improved after rennin-angiotensin system was blocked. Visfatin may play an important role in the pathogenesis of insulin resistance.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2007年第3期273-274,共2页
Chinese Journal of Endocrinology and Metabolism
基金
湖北省自然科学基金资助(No:2005ABA158)
