非霍奇金淋巴瘤长期存活的因素分析

Analysis of Factors Related to Long-term Survival in Patients with Non-Hodgkin's Lymphoma

目的探讨非霍奇金淋巴瘤(NHL)长期存活的因素。方法105例NHL患者随机分为单纯化疗组、单纯放疗组和综合组,治后随访5年,从性别、病理类型、临床分期、治前病程、治疗方法、初治疗效等6个方面进行统计分析。结果全组总有效率(CR+PR)为88·6%,1、3、5年生存率分别为67·6%(71/105)、46·7%(49/105)、37·1%(39/105)。性别对生存率无明显影响,病理类型、疗前病程、治疗方法及初治疗效对生存率有着重要影响。结论影响NHL预后的主要因素有病理类型、临床分期、治疗方法、初治疗效、治前病程等,治疗方法是唯一能够选择的对本病预后有直接影响的因素,以中药加化疗加放疗的综合治疗疗效最好。

Objective To evaluate the long - term survival factors of the patients with Non - Hodgkin＇s lymphoma （NHL）. Methods 105 patients with NHL were randomly divided into three groups, include chemotherapy group, radiotherapy group and combined group. The median follow -up period was 5 years. The results were analyzed in six aspects： patient＇s sex, pathological type, clinical stage, course of disease before the treatment, therapy methods, therapy effects of early stages. Results The total response rate of three groups was 88.6%. The survival rate was 67.6% （71/105） in the first year,46. 7% （49/105）in the third year,37.1% （39/105） in the fifth year. The survival rates were not significant difference between patient＇s sex. The survival rates were affected by pathological type, clinical stage, course of disease before the treatment, therapy methods, therapy effects of early stages significantly. Conclusion The chief factors of affecting NHL patient＇s prognosis involved pathological type, clinical stage, course of disease before the treatment, therapy methods, therapy effects of early stages. The therapy method was the only direct prognostic factor, and the combined therapy was the best one.