硝酸异山梨酯静脉内输注治疗冠心病心绞痛102例

Isosorbide dinitrate intravenous infusion in treatment of angina pectoris in 102 patients

目的：比较国产与进口硝酸异山梨酯注射液治疗冠心病心绞痛的疗效。方法：冠心病心绞痛病人１５２例，其中１０２例（男性６７例，女性３５例，年龄６３±ｓ９ａ）以国产硝酸异山梨酯注射液２０ｍｇ加于５％葡萄糖液５００ｍＬ中静脉滴注，ｑｄ，连用１４ｄ。另外５０例（男性３５例，女性１５例；年龄６４±８ａ）以德国进口硝酸异山梨酯注射液２０ｍｇ加入５％葡萄糖液５００ｍＬ中静脉滴注，ｑｄ，连用１４ｄ。结果：国产组临床总有效率为９４．１％，心电图总有效率为４８．０％，进口组则依次为９６％与５２％；组间比较，Ｐ值均＞０．０５。该药尚有扩张血管、降低血压、减低心肌氧耗，改善左室功能等作用。结论：本药的疗效和作用与进口硝酸异山梨酯注射液相近。

AIM: To compare the clinical efficacy of domestic and imported isosorbide dinitrate in treatment of angina pectoris. METHODS: One hundred and two patients (M 67, F 35; age 63±s 9 a) of coronary disease with angina pectoris were treated with domestic preparation and 50 patients (M 35, F 15; age 64±8 a) were treated with imported preparation, both were infused 20 mg plus 5% glucose 500 mL, iv, gtt qd for 14 d. RESULTS: The total clinical effective rate was 94.1%, ECG effective rate was 48.0% for domestic group; and 96% and 52% respectively for imported group.The drug dilated blood vessels, reduced blood pressure and myocardial O 2 consumption, and improved left ventricular function. CONCLUTION: The effects of domestic and imported isosorbide dinitrate are similar.