东菱克栓酶冠状动脉溶栓治疗急性心肌梗塞的临床研究

Intracoronary thrombolytic therapy by batroxobin in acute myocardial infarction

报告6例发病时间在4～10小时内的急性心肌梗塞患者，采用冠状动脉狭窄口堵塞近端注入东菱克栓酶（DF－521）20～30BU（Batroxobinunit简称BU，是Batroxobin的酶活性量的表示单位。37℃以下，标准人～枸椽酸血浆0．3ml中加入Batroxobin溶液0．1ml，19．0±0．2秒发生凝固时其酶活性为2BU）。进行溶栓治疗，60～90分钟后重复冠状动脉造影。结果全部有效，4例闭塞管腔再通（TIMI达Ⅲ级）2例大部分再通（TIMI达Ⅱ级），从而限制了梗塞发展且无出血及其它并发症，效果显著，值得进一步研究推广。

Six patients with acute myocardial infarction (AMI) who were treated with an intracoronary infusion of batroxlbin (20 ~ 30 BU) within 4 ~ 10 hours after the onset of symptoms were reported. Repeated coronary angiography was achieved at 60~90 min after thrombolytic therapy. We found that pateney of the occuluded vessel occurred in all cases. TIMI grade 2 flow were present in the infaret-related artery in 2 patients and TIMI grade 3 flow in 4 patients. Thus,expansion of the infarction arear was Limited and there were no serious complication. The result showed that this therapy has obvions efficacy.