糖尿病鼠各组织 β- 内啡肽、亮啡肽和强啡肽 A_(1-13)的变化

Changes of β EP、L EK and DynA 1 13 in several tissues of diabetic rats

用链脲菌素（ＳＴＺ）复制ＳＤ鼠糖尿病模型后，观察不同病程（糖尿病后３、６、９周）其下丘脑、垂体、胰腺和血浆中β－内啡肽（β－ＥＰ）、亮啡肽（Ｌ－ＥＫ）和强啡肽Ａ１－１３（ＤｙｎＡ１－１３）的变化。结果：随病程的延长，病程第６、９周三种阿片肽在各组织平行下降，尤以ＤｙｎＡ１－１３明显。

Changes of opioid peptides in several tissues from hypothalamus, hypophysis, pancreas and plasma of streptozotocin induced diabetic rats were observed during different courses(3,6,9 weeks). The results demonstrated that the three opioid peptides(β endorphin, Leu enkephalin, DynerphinA 1 13 ) in all the tissues decreased parallelly at 6 and 9 weeks duration. The most obvious decrease was from DynA 1 13 .