摘要
采用吡喃糖氧化酶（ＰＲＯＤ）法检测１，５－脱水山梨醇（１，５－ＡＧ）浓度。正常人（７５例）为２９．８４±９．９１ｍｇ／Ｌ，正常下限为１３．５ｍｇ／Ｌ；ＩＧＴ者（１８例）为１８．６１±４．６５ｍｇ／Ｌ；糖尿病患者（１８８例）为６．５８±４．２６ｍｇ／Ｌ，三者间呈显著性差异（Ｐ＜０．００１），糖尿病患者１，５－ＡＧ值比正常人低４５％。１，５－ＡＧ分别与空腹血糖（ｒ＝－０．７０６０）、２４小时尿糖（ｒ＝－０．８５３３）、果糖胺（ｒ＝－０．６７５９）、糖化血红蛋白（ｒ＝－０．５９１１）均呈显著负相关，提示１，５－ＡＧ可用作糖尿病监测新指标。同时还证明１，５－ＡＧ尚可反映过去一周内短期的平均血糖水平，因此弥补了过去缺乏短期指标之不足。
Serum 1,5 AG concentration was determined by pyranose oxidase(PROD) method. Mean 1,5 AG values were 29.84±9.91mg/L in the healthy individuals (n=75) with 13.5mg/L as the normal lower limit, 18.61±4.65mg/L in IGT(n=18), and 6.58±4.26mg/L in diabetic subjects(n=188) There were significant difference among the three groups (P<0 001),1,5 AG concentration was 45% lower in diabetic patients than that in healthy. 1,5 AG level had significantly negative correlation with FBG(r=-0 7060)、UG/24h(r=-0.8533)、FRA(r=-0.6759) and GHb(r=-0.5911) respectively. It may be used as a new marker for monitoring diabetes mellitus. Besides, 1,5 AG concentration reflects glycemic status one week prior to its measurement
出处
《中国糖尿病杂志》
CAS
CSCD
1997年第2期89-92,共4页
Chinese Journal of Diabetes
