大黄醇提液抗家兔实验性动脉粥样硬化作用的病理形态学研究

Pathological Study on Anti-experimental Atherosclerotic Effects of Rhubarb Ethanol-extract in Rabbits

将30只雄性健康新西兰白兔随机分为5组,每组6只。对照组给予基础饲料;模型组给予高脂饲料;三个大黄组给予高脂饲料同时分别用不同药量的大黄醇提液灌胃。于第10周末处死家兔,观察、测量和比较主动脉弓、胸主动脉、腹主动脉和髂动脉分支处血管脂质斑块的病理变化,计算斑块面积占胸主动脉的百分比;光镜下观察心脏冠状血管的病理改变,并计算冠状小动脉粥样硬化的发生率,研究大黄醇提液抑制家兔动脉粥样硬化形成的作用。结果显示:大黄醇提液能一定程度上抑制家兔主动脉及腹主动脉AS形成,减少AS斑块面积,降低动脉分支处AS的发生率,减轻心脏冠状动脉AS的病变。

Thirty healthy male white rabbits were divided randomly into five groups, six rabbits per group. The rabbits in control group were fed with common forage. The rabbits in model group were fed with high lipid forage. The rabbits in three rhubarb groups were fed with high lipid forage and administrated intragastrically with different dosage of rhubarb ethanol-extract （REE）. The rabbits were killed at the end of the tenth week, the atherosclerosis （AS） plaque areas of aorta were measured and the percentage of AS plaques covering aortic intima （PA） was calculated. The pathological changes of coronary arteries were observed with microscope and the incidence of atherosclerosis of small coronary arteries was calculated. The results indicated that REE could inhibit the progression of aortic and abdominal aortic intimal AS plaques and decrease the incidence of AS in artery branch. REE also could reduce AS formation in coronary arteries.