红细胞内镁浓度与慢性肺原性心脏病的关系

Study on the relationship between red cell magnesium concentration and cardiopulmonary function in chronic cor pulmonale/

目的：评价慢性肺原性心脏病（肺心病）急性发作期血浆和红细胞内Ｍｇ２＋浓度与心肺功能间的关系。方法：用原子吸收分光光度计检测３１例正常人和４１例肺心病患者血浆和红细胞内Ｍｇ２＋浓度。结果：４１例肺心病患者中２１例次（５１．２２％）显示红细胞内低镁（平均Ｍｇ２＋浓度≤１４．４２ｍｍｏｌ／Ｌ），３３例次（８０．４９％）显示血浆低镁（平均Ｍｇ２＋浓度≤８．８３ｍｍｏｌ／Ｌ）；红细胞内低镁时Ｍｇ２＋浓度与１秒率ＦＥＶ１％呈正相关，血浆低镁时Ｍｇ２＋浓度与ＦＥＶ１％无相关性；红细胞内低镁者心律失常的发生率（９０．４８％）比血浆低镁者的心律失常发生率（６０．６０％）要高，Ｐ＜０．０５。结论：肺心病时存在低镁血症，因此监测红细胞内Ｍｇ２＋浓度极为重要；给肺心病急性发作期患者及时补充镁盐有利于患者心肺功能的恢复。

Objective:To evaluate the relationship between red cell magnesium concentration (MgRC),plasma magnesium concentration (MgPL) and cardiopulmonary function in chronic cor pulmonale.Methods:The MgRC and MgPL of 31 healthy individuals and 41 selected patients with chronic cor pulmonale were measured by atomic absorption spectrophotometry.Results:Among 41 patients,21 patients had decreases in MgRC (14.58±1.34 mmol/L,51.22%) and 33 patients in MgPL (8.10±0.88 mmol/L,80.49%).There was significant positive correlation between the decrease of MgRC and forced expiratory volume in one second (FEV 1%),while no correlation between the decrease of MgPL and FEV 1% was found.Moreover,MgRC or MgPL was associated with the attack of arrhythmia,but the incidence of arrhythmia with decrease of MgRC (90.48%) was higher than that of arrhythmia with the decrease of MgPL (60.60%, P <0 05).Conclusions:There exists decreased magnesemia in chronic cor pulmonale,thus it is important to monitor the MgRC in those patients.In addition,it is necessary to administer magnesium immediately to the patients with chronic cor pulmonale,which may be of benefit for the recovery of cardiopulmonary function.