摘要
目的:研究C-met、P53基因在前列腺癌中的表达及意义。方法:采用免疫组化方法检测72例前列腺癌组织中P53、C-met蛋白的表达。结果:①P53和C-met在前列腺癌的阳性表达率分别为51.4%和59.7%。两种蛋白的表达与其肿瘤的分级和分期呈正相关(P<0.05);②C-met、P53蛋白表达与病人的生存期有关(P<0.01);③P53、C-met蛋白表达之间存在相关性(P<0.05)。结论:P53、C-met蛋白的异常表达与前列腺癌的发展及预后有关。
OBJECTIVE：To study the expression and significance of P53 protein and C -met protein in prostatic carcinoma, METHOD：Immunohistochemical staining method was used to evaluate the positivity of P53 and C - met in 72 cases of prostatic carcinoma. RESULTS：①The positive rates of P53 protein and C -met protein expression were 51.4% and 59. 7% respectively. Expression of the two proteins showed positive correlation with grade and stage of the tumor（ P 〈 0. 05） ;②Expression of P53 protein correlated with survival time of these patients. （ P 〈 0. 05 ） ; ③ There was relation between P53 and c - met （ P 〈 0.05 ）CONCLUSION： Over expression of P53 and c - met protein might be related to the progression and prognosis of prostate carcinoma.
出处
《九江医学》
CAS
2007年第2期4-7,共4页
Jiujiang Medical Journal
