宽QRS波群心动过速应用胺碘酮静脉注射治疗的即时疗效和安全性研究

Study on the Safety and Efficacy of Intravenous Amiodarone for Broad QRS Tachycardia

目的:观察和比较静脉注射胺碘酮、普罗帕酮治疗宽QRS波群心动过速的即时疗效和安全性。方法:40例宽QRS波群心动过速患者随机分为治疗组和对照组各20例,治疗组和对照组分别用胺碘酮150mg(3～5mg/kg)稀释于20mL生理盐水中和普罗帕酮70mg加入10%葡萄糖20mL中5～10min内静脉注射完毕,其后以1mg/min静滴,观察15min,若无效,则分别再予75mg和35mg静注。结果:治疗组和对照组治疗宽QRS波群心动过速的总有效率分别为90%和60%,平均起效时间分别为(12.6±5.8)min和(8.3±4.2)min。两组均未见有心衰加重和促心律失常作用表现。结论:静脉注射胺碘酮能迅速、安全、有效地治疗宽QRS波群心动过速。

Objective： To compare the efficacy and safety of intravenous amiodarone and propafenone for broad QRS taehyeardia. Methods： 40 patients with broad QRS tachyeardia were randomly divided into treatment group and control group and each group was 20 eases, patients and 20 patients in propafenone group as control. Patients in treatment group and control group were received amiodarone 150 rag （3-5 mg/kg） with 20 mL NS and propafenone 70 mg with 20 mL 10% Glucose Ⅳ in 5～10 mins, followed by infusion at 1.0 mg/min for 15 minutes. If unfruitful, repeat 75 mg and 35mg bolusec after the first loading prospectively. Results： The cure rate and efficacy time were 90% ＆ 60% and 12.6± 5.8 mins ＆ 8.3±4.2 mins in treatment group and control group prospectively. There were no tachycardia and heart failure. Conclusion ：It is safe and effective for broad QRS tachycardia to intravenous amiodarone.