急性发作期哮喘血清与免疫球蛋白的临床意义

Significance of Cytokines and Immunoglobulin in Acute Asthmatic Patients

目的:探讨急性发作期哮喘患者血清细胞因子及免疫球蛋白水平的意义。方法:对急性发作期哮喘患者56例及健康人46例进行TNF-α、IL-4、IL-6、IL-8和免疫球蛋白水平测定并作相关性分析。结果:哮喘患者血清TNF-α、IL-4、IL-6、IL-8及IgE、IgG水平明显高于对照组(P<0.05);IgE与TNF-α、IL-4IL-6、IL-8均呈正相关(P<0.01或P<0.001)。结论:TNF-α、IL-4、IL-6、IL-8是参与急性发作期哮喘患者气道炎症的重要细胞因子,针对细胞因子在气道炎症中作用的不同特点采取治疗十分必要。

Objective： To explore the significance of cytokines and in acute asthmatic patients. Methods： Analyzing the correlation of TNF-α.IL-4 .IL-6.IL-8 and immunoglobulin between 56 acute asthmatic patients and 46 health people. Results： The serum level of TNF-α.IL-4.IL-6.IL-8.IgE and IgG in acute asthmatic patients was higher than the health people,P 〈 0.05. The serum level of TNF-α.IL-4.IL-6.IL-8 was positive relative to IgE for acute asthmatic patients. Conclusion： TNF-α.IL-4 .IL-6 and IL-8 were important cytokines in acute asthmatic patients, and according to the different properties of TNF-α.IL-4 .IL-6.IL-8 in respiratory inflammation is necessary.