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辛伐他汀对急性脑梗死患者血浆t-PA和PAI-1水平的影响

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摘要 目的探讨辛伐他汀对急性脑梗死(acute cerebral infarction,ACI)患者血浆t-PA和PAI-1水平的影响。方法将50例急性脑梗死患者随机分为治疗组和对照组,2组均给予脱水、营养脑细胞等常规治疗,治疗组在常规治疗的基础上加用辛伐他汀,2组均未给予抗凝、溶栓、降纤治疗,测定用药前及用药4周后的血浆t-PA和PAI-1的含量。结果2组用药前血浆t-PA和PAI-1的含量无明显差异(P>0.05),治疗4周后治疗组血浆t-PA含量明显高于对照组(P<0.05),PAI-1含量明显低于对照组(P<0.05)。结论辛伐他汀能升高急性脑梗死患者血浆tPA-1含量,降低血浆PAI-1含量,提高体内纤溶状态,治疗急性脑梗死有效。
出处 《中国实用神经疾病杂志》 2007年第4期69-70,共2页 Chinese Journal of Practical Nervous Diseases
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参考文献8

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