丝裂霉素C联合羊膜移植治疗翼状胬肉的临床观察

Clinical study on mitomycin C combined with amniotic membrane transplantation in the treatment of pterygium

目的评价丝裂霉素C联合羊膜移植治疗翼状胬肉及预防其复发的临床效果。方法将320例(496眼)翼状胬肉患者随机分为2组,每组248眼。治疗组施以翼状胬肉切除术加羊膜移植术联合丝裂霉素C治疗,对照组仅施以翼状胬肉切除术加羊膜移植术,观察比较2组患者的疗效及复发情况。结果经12～24个月的随访,治疗组胬肉复发8例8眼(其中7例患者年龄<60岁),复发率为3.23%。对照组复发21例21眼(其中18例患者年龄<60岁),复发率为8.47%,治疗组复发率明显低于对照组,差异有统计学意义(P<0.01)。结论单纯性翼状胬肉患者施行丝裂霉素C联合羊膜移植术,可使术后复发率降低。

Objective To evaluate the therapeutic and preventive effects of mitomycin C combined with amniotic membrane transplantation on pterygium. Methods Three hundred and twenty patients （496 eyes） with simple pterygium were randomly divided into two groups. 248 eyes in trial group were treated by mitomycin C combined with amniotic membrane transplantation after resection of pterygium,however,the other 248 eyes in control group were trea- ted only by resection of pterygium combined with amniotic membrane transplantation. The therapeutic effect and recurrence rate were observed and compared between the two groups. Results After 12 - 24 months＇ follow-up,8 cases （8 eyes） recurred in trial group （7 cases〈 60 years） ,and recurrence rate was 3.23%. 21 cases （21 eyes） recurred in control group （ 18 cases 〈 60 years）, and recurrence rate was 8.47 %. The recurrence rate in trial group was significantly lower than that of control group （ P 〈 0.01）. Conclusion The mitomycin C combined with amniotic membrane transplantation could reduce the recurrence rate after resection of pterygium in patients with simple pterygium.