摘要
抗真菌药萘替芬的合成ＳＹＮＴＨＥＳＩＳＯＦＡＮＴＩＭＹＣＯＴＩＣＡＧＥＮＴＮＡＦＴＩＦＩＮＥ左淑芳＊杨凤艳（河北省药物研究所，石家庄０５００６１）ＺＵＯＳｈｕ－Ｆａｎｇ＊，ＹＡＮＧＦｅｎｇ－Ｙａｎ（ＨｅｂｅｉＰｈａｒｍａｃｅｕｔｉｃａｌＩｎｓｔｉｔｕ...
Ribavirin (1) was enzymatically synthesized from guanosine and 1,2,4 triazole 3 carboxamide (TCA) by intact cells of Brevibacterium acetylicum TQ 952 with equal amount of 200mmol/L guanosine and TCA. 1 was produced in 155.6mmol/L(78%yield) at 65℃ with 50mg/ml of cells (wet base) in 25mmol/L(pH7.0) phosphate buffer after 24h.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1997年第1期8-9,共2页
Chinese Journal of Pharmaceuticals
关键词
萘替芬
抗真菌药
合成
ribavirin, Brevibacterium acetylicum , nucleoside phosphorylase
